Format

Send to

Choose Destination
Afr J Tradit Complement Altern Med. 2017 Jan 13;14(2):92-102. doi: 10.21010/ajtcam.v14i2.11. eCollection 2017.

EVALUATION OF THE CHELATING EFFECT OF METHANOLIC EXTRACT OF CORIANDRUM SATIVUM AND ITS FRACTIONS ON WISTAR RATS POISONED WITH LEAD ACETATE.

Author information

1
Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango. Articulo 123 S/N Fraccionamiento Filadelfia. Gómez Palacio Durango, C.P. 35010, México.
2
Facultad de Ciencias Biológicas, Universidad Juárez del Estado de Durango. Artículo 123 S/N Fraccionamiento Filadelfia. Gómez Palacio Durango, C.P. 35010, México.
3
Departamento de Bioquímica y Farmacología, Centro de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Coahuila, Unidad Torreón. Gregorio A. García 198 Sur, Torreón, Coahuila, C.P. 27000, México.
4
Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Coahuila, Unidad Torreón. Morelos No. 900 Ote. Torreón, Coahuila. México. C.P. 27000, México.
5
Departamento de Biología Celular y Ultra estructura, Centro de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Coahuila, Unidad Torreón. Gregorio A. García 198 Sur, Torreón, Coahuila. México. C.P. 27000, México.

Abstract

BACKGROUND:

The rate of lead poisoning has decreased in recent years due to increased health control in industries that use this metal. However, it is still a public health problem worldwide. The use of various plants with chelating properties has been a topic of research today. In traditional medicine, it is said that Coriandrum sativum has chelating properties, but there is no scientific evidence to support this fact. The purpose of this research is to evaluate the chelating effect of methanol extract of coriander and its fractions on Wistar rats intoxicated with lead.

MATERIALS AND METHODS:

In this research, male Wistar rats were poisoned with 50 mg/kg of lead acetate and treated with 50 mg/kg of methanol extract and its fractions. The extract and its fractions were administered to four treatment groups. Positive and negative controls were established. Hemoglobin, hematocrit and lead concentrations were analyzed; liver was evaluated histologically in control and treatment groups.

RESULTS:

The methanol extract of coriander presented a LD50 >1000 mg/dL. The group administered with the methanol extract showed significant difference in the levels of hemoglobin and hematocrit compared to the negative control group. Lead concentration in treatment groups showed a decrease compared to the positive control. Histological evaluation of tissue showed less damage in groups administered with methanolic extract and its fractions compared to the positive control which presented structural alterations.

CONCLUSION:

Coriander extracts protect liver and lower lead concentration in rats intoxicated with lead in contrast to the positive control group.

KEYWORDS:

Coriandrum sativum; Lead; chelatin effect; natural products

PMID:
28573226
PMCID:
PMC5446471
DOI:
10.21010/ajtcam.v14i2.11
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center