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Clin Med (Lond). 2017 Jun;17(3):274-277. doi: 10.7861/clinmedicine.17-3-274.

Thyrotoxicosis - investigation and management .

Author information

1
King's College Hospital, Denmark Hill, London jackiegilbert@nhs.net.

Abstract

Graves' disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Thionamides achieve long-term remission in 35% of cases. Many centres administer fixed doses of iodine-131; larger doses result in improved rates of cure at the cost of hypothyroidism. Surgery is usually considered for patients who have a large goitre, compressive symptoms or significant ophthalmopathy.

KEYWORDS:

Grave’s disease; radioiodine; thionamides; thyroidectomy; thyrotoxicosis

PMID:
28572231
PMCID:
PMC6297572
DOI:
10.7861/clinmedicine.17-3-274
[Indexed for MEDLINE]
Free PMC Article

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