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J Clin Psychiatry. 2017 May;78(5):e522-e528. doi: 10.4088/JCP.16m10772.

A Pilot, Randomized Controlled Study of Tai Chi With Passive and Active Controls in the Treatment of Depressed Chinese Americans.

Author information

1
MGH Depression Clinical and Research Program, One Bowdoin Sq, 6/F, Boston, MA 02114. ayeung@mgh.harvard.edu.
2
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA.
3
Benson Henry Institute for Mind Body Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
4
Osher Center for Integrative Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
5
School of Social Work, University of North Carolina, Charlotte, North Carolina, USA.

Abstract

OBJECTIVE:

This pilot, randomized clinical trial investigates the effectiveness of tai chi as the primary treatment for Chinese Americans with major depressive disorder (MDD).

METHODS:

67 Chinese Americans with DSM-IV MDD and no treatment for depression were recruited between March 2012 and April 2013 and randomized (1:1:1) into a tai chi intervention, an education program, or a waitlisted group for 12 weeks. The primary outcome measure was the 17-item Hamilton Depression Rating Scale (HDRS₁₇); positive response for this outcome was defined as a decrease in total score of 50% or more, and remission was defined as HDRS₁₇ ≤ 7.

RESULTS:

Participants (N = 67) were 72% female with a mean age of 54 ± 13 years. No serious adverse events were reported. After the end of the 12-week intervention, response rates were 25%, 21%, and 56%, and remission rates were 10%, 21%, and 50% for the waitlisted, education, and tai chi intervention groups, respectively. The tai chi group showed improved treatment response when compared to both the waitlisted group (odds ratio [OR] = 2.11; 95% CI, 1.01-4.46) and to the education group (OR = 8.90; 95% CI, 1.17-67.70). Tai chi intervention showed significantly improved remission rate over the waitlisted group (OR = 3.01; 95% CI, 1.25-7.10), and a trend of improved remission compared to the education group (OR = 4.40; 95% CI, 0.78-24.17).

CONCLUSIONS:

As the primary treatment, tai chi improved treatment outcomes for Chinese Americans with MDD over both passive and active control groups.

TRIAL REGISTRATION:

ClinicalTrials.gov identifier: NCT01619631.

PMID:
28570792
DOI:
10.4088/JCP.16m10772
[Indexed for MEDLINE]

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