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J Surg Oncol. 2017 Nov;116(6):730-740. doi: 10.1002/jso.24701. Epub 2017 Jun 1.

Sensitivity and specificity of indocyanine green near-infrared fluorescence imaging in detection of metastatic lymph nodes in colorectal cancer: Systematic review and meta-analysis.

Author information

1
Mansoura Faculty of Medicine, Department of General Surgery, Colorectal Surgery Unit, Mansoura University, Mansoura, Dakahlia, Egypt.
2
Department of Surgery, Aarhus University Hospital, Aarhus, Denmark.
3
Department of General Surgery, University of Rome Tor Vergata, Rome, Italy.
4
Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida.

Abstract

This review aimed to determine the overall sensitivity and specificity of indocyanine green (ICG) near-infrared (NIR) fluorescence in sentinel lymph node (SLN) detection in Colorectal cancer (CRC). A systematic search in electronic databases was conducted. Twelve studies including 248 patients were reviewed. The median sensitivity, specificity, and accuracy rates were 73.7, 100, and 75.7. The pooled sensitivity and specificity rates were 71% and 84.6%. In conclusion, ICG-NIR fluorescence is a promising technique for detecting SLNs in CRC.

KEYWORDS:

colorectal cancer; fluorescence; indocyanine green; lymph nodes; sensitivity; specificity

PMID:
28570748
DOI:
10.1002/jso.24701
[Indexed for MEDLINE]

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