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Chem Rev. 2017 Sep 27;117(18):11796-11893. doi: 10.1021/acs.chemrev.7b00183. Epub 2017 Jun 1.

The Hitchhiker's Guide to Flow Chemistry ∥.

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1
Department of Biomolecular Systems, Max-Planck Institute of Colloids and Interfaces , Am Mühlenberg 1, 14476 Potsdam, Germany.
2
Institute of Chemistry and Biochemistry, Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin , Arnimallee 22, 14195 Berlin, Germany.

Abstract

Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous stream rather than in a flask. Flow equipment provides chemists with unique control over reaction parameters enhancing reactivity or in some cases enabling new reactions. This relatively young technology has received a remarkable amount of attention in the past decade with many reports on what can be done in flow. Until recently, however, the question, "Should we do this in flow?" has merely been an afterthought. This review introduces readers to the basic principles and fundamentals of flow chemistry and critically discusses recent flow chemistry accounts.

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