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Nat Protoc. 2017 Jul;12(7):1289-1294. doi: 10.1038/nprot.2017.040. Epub 2017 Jun 1.

Quantitative proteomics: challenges and opportunities in basic and applied research.

Author information

1
Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, USA.
2
Department of Genetics, Stanford University, Stanford, California, USA.
3
Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
4
Faculty of Science, University of Zurich, Zurich, Switzerland.

Abstract

In this Perspective, we discuss developments in mass-spectrometry-based proteomic technology over the past decade from the viewpoint of our laboratory. We also reflect on existing challenges and limitations, and explore the current and future roles of quantitative proteomics in molecular systems biology, clinical research and personalized medicine.

PMID:
28569762
DOI:
10.1038/nprot.2017.040
[Indexed for MEDLINE]

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