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Contemp Clin Dent. 2017 Jan-Mar;8(1):116-121. doi: 10.4103/ccd.ccd_836_16.

Effect of Freeze Dried Powdered Probiotics on Gingival Status and Plaque Inhibition: A Randomized, Double-blind, Parallel Study.

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Department of Public Health Dentistry, Government Dental College, Srinagar, Jammu and Kashmir, India.
Department of Pedodontics and Preventive Dentistry, Government Dental College, Srinagar, Jammu and Kashmir, India.
Department of Public Health Dentistry, Jaipur Dental College, Jaipur, Rajasthan, India.
Masters in Public Health (MPH) Student, Hamburg University of Applied Sciences, Hamburg, Germany.
Intern, Government Dental College, Srinagar, Jammu and Kashmir, India.



The study aimed to evaluate the effectiveness of freeze dried powdered probiotics on gingival status and plaque inhibition among 12-15-year-old schoolchildren.


This randomized controlled trial was conducted among 12-15-year-old schoolchildren in Jaipur. Commercially available freeze dried probiotics containing Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium bifidum and Bifidobacterium lactis (Prowel, Alkem Laboratories), lactic acid bacillus only (Sporolac, Sangyo), and a placebo powder calcium carbonate 250 g (Calcium Sandoz, Novartis) were assigned to two intervention groups and a placebo group each comprising 11 schoolchildren. All subjects were instructed to mix the powder in 30 ml of water and swish once daily for 3 min, for 3 weeks. Periodontal clinical parameters were assessed by examining the subjects for Turesky-Gilmore-Glickman plaque index (PI) (Modification of Quigley-Hein PI) and gingival index at baseline, 7th day, 14th day, and 21st day.


For both the probiotic groups, a statistically significant reduction (P < 0.05) in gingival status and plaque inhibition was recorded up to 2nd week of probiotic ingestion. However, no significant difference was observed in the placebo group.


The use of probiotic mouth rinses improves the oral health in children by significantly reducing the plaque and gingival scores. Further studies are warranted to prove or refute the long-term effects, means of administering probiotics and the dosages needed to achieve different preventive or therapeutic purposes.


Bacteriotherapy; Bifidobacteria; Lactobacillus; oral ecology; probiotic

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