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J Nutr. 2017 Jul;147(7):1348-1355. doi: 10.3945/jn.117.248419. Epub 2017 May 31.

A Mediterranean Diet Reduces F2-Isoprostanes and Triglycerides among Older Australian Men and Women after 6 Months.

Author information

Alliance for Research in Exercise, Nutrition, and Activity, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia;
School of Psychology, Social Work, and Social Policy, University of South Australia, Magill, Adelaide, South Australia, Australia.
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia; and.
Flinders Centre for Epidemiology and Biostatistics, Flinders University, Flinders Medical Centre, Bedford Park, South Australia, Australia.
Alliance for Research in Exercise, Nutrition, and Activity, School of Health Sciences, University of South Australia, Adelaide, South Australia, Australia.


Background: Health benefits of a Mediterranean dietary pattern have been shown. However, there are few data on the effects of increased adherence to a Mediterranean diet (MedDiet) in non-Mediterranean countries.Objective: We aimed to determine whether adherence to a MedDiet would result in changes in plasma lipids, glucose and insulin, high-sensitivity C-reactive protein (hs-CRP), and F2-isoprostanes (F2-IsoPs) in an Australian population.Methods: The study was a 6-mo parallel, randomized, controlled dietary intervention trial. We recruited 166 participants aged ≥65 y. Participants were stratified on body mass index, sex, and age and assigned to receive either a MedDiet or a habitual diet (HabDiet). The primary outcome was cognitive function, reported elsewhere. As secondary outcomes, assessment of fasting total, LDL, and HDL cholesterol; triglycerides (TGs); glucose; insulin; hs-CRP; and F2-IsoPs was completed at baseline and at 3 and 6 mo. The MedDiet group followed a prescribed diet containing 15-45 mL extra-virgin olive oil/d, abundant vegetables, fruit, nuts, legumes, and whole grains, as well as moderate fish, poultry, and dairy foods. Dietary intake was measured by 3-d weighed food records at baseline and at 2 and 4 mo. Results were analyzed by using linear mixed-effects models.Results: Compared with the HabDiet, the MedDiet resulted in lower TGs at 3 mo (mean difference: -0.15 mmol/L; 95% CI: -0.23, -0.07 mmol/L; P < 0.001) and 6 mo (mean difference: -0.09 mmol/L; 95% CI: -0.18, -0.01 mmol/L; P = 0.03) and lower F2-IsoPs at 3 mo (mean difference: -103.5 pmol/L; 95% CI: -154.2, -52.7 pmol/L; P < 0.001) and 6 mo (-65.4 pmol/L; 95% CI: -117.1, -13.7 pmol/L; P < 0.001). Lipoprotein, glucose and insulin, and hs-CRP concentrations were not significantly different between groups.Conclusion: A high adherence to a MedDiet for 6 mo resulted in a significant reduction in TGs and F2-IsoPs among older Australians. This trial was registered at as ACTRN12613000602729.


F2-isoprostanes; Mediterranean diet; cardiovascular risk factors; older Australians; oxidative stress

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