A new therapeutic target for myelofibrosis is cause for Gli

Sci Transl Med. 2017 May 31;9(392):eaan4297. doi: 10.1126/scitranslmed.aan4297.

Abstract

Myeloproliferative neoplasm cells recruit Gli1 positive mesenchymal stromal cells to transdifferentiate into fibrosis-causing myofibroblasts, a process that can be inhibited by a Gli inhibitor.

Publication types

  • Comment

MeSH terms

  • Fibrosis
  • Humans
  • Mesenchymal Stem Cells*
  • Myofibroblasts
  • Primary Myelofibrosis*
  • Zinc Finger Protein GLI1

Substances

  • GLI1 protein, human
  • Zinc Finger Protein GLI1