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Nat Commun. 2017 May 31;8:15314. doi: 10.1038/ncomms15314.

Engineered clearing agents for the selective depletion of antigen-specific antibodies.

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Department of Molecular and Cellular Medicine, Texas A&M University Health Science Center, 469 Joe H. Reynolds Medical Sciences Building, 1114 TAMU, College Station, Texas 77843, USA.
Department of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, 3107 Medical Research &Education Building, 8447 State Highway 47, Bryan, Texas 77807, USA.
Department of Biomedical Engineering, Texas A&M University, 5045 Emerging Technologies Building, 3120 TAMU, College Station, Texas 77843, USA.


Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.

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