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Front Cell Neurosci. 2017 May 16;11:140. doi: 10.3389/fncel.2017.00140. eCollection 2017.

Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells.

Author information

1
Douglas Mental Health University Institute, Department of Psychiatry, McGill University, MontrealQC, Canada.
2
Institut für Integrative Neuroanatomie Research CenterBerlin, Germany.
3
Sorbonne Universités, UPMC Univ Paris 06, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Medicale, Institut de Biologie Paris Seine, Neuroscience Paris Seine (NPS)Paris, France.
4
Université Paris Descartes, Sorbonne Paris Cité, Centre National de la Recherche Scientifique, UMR 8250Paris, France.
5
OramacellParis, France.
6
Sorbonne Universités, UPMC Univ Paris 06, CNRS, Core Facilities - Institut de Biologie Paris SeineParis, France.
7
CNRS UMR 7364, Team NCD, Université de StrasbourgStrasbourg, France.

Abstract

Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3); therefore, these cells have the ability to signal with both GABA and glutamate. GABAergic transmission by basket cells has been extensively characterized but nothing is known about the functional implications of VGLUT3-dependent glutamate released by these cells. Here, using VGLUT3-null mice we observed that the loss of VGLUT3 results in a metaplastic shift in synaptic plasticity at Shaeffer's collaterals - CA1 synapses and an altered theta oscillation. These changes were paralleled by the loss of a VGLUT3-dependent inhibition of GABAergic current in CA1 pyramidal layer. Therefore presynaptic type III metabotropic could be activated by glutamate released from VGLUT3-positive interneurons. This putative presynaptic heterologous feedback mechanism inhibits local GABAergic tone and regulates the hippocampal neuronal network.

KEYWORDS:

basket cell; glutamate/GABA co-transmission; hippocampus; type III mGluRs; vesicular glutamate transporter type 3

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