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Sci Rep. 2017 May 30;7(1):2482. doi: 10.1038/s41598-017-02753-6.

Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior.

Author information

1
Department of Neurosurgery, Rhode Island Hospital, Providence, RI, USA.
2
Department of Neuroscience, Brown University, Providence, RI, USA.
3
Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
4
Center for Biomedical Engineering, Brown University, Providence, RI, USA.
5
Laboratory for Pharmacology, Asahi KASEI Pharma Corporation, Shizuoka, Japan.
6
Department of Neurosurgery, Rhode Island Hospital, Providence, RI, USA. carl_saab@brown.edu.
7
Department of Neuroscience, Brown University, Providence, RI, USA. carl_saab@brown.edu.

Abstract

We tested the relation between pain behavior, theta (4-8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.

PMID:
28559582
PMCID:
PMC5449396
DOI:
10.1038/s41598-017-02753-6
[Indexed for MEDLINE]
Free PMC Article

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