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Regul Toxicol Pharmacol. 2017 Aug;88:144-156. doi: 10.1016/j.yrtph.2017.05.017. Epub 2017 May 27.

Integrating habits and practices data for soaps, cosmetics and air care products into an existing aggregate exposure model.

Author information

Creme Global Ltd, The Tower, Trinity Enterprise Centre, Grand Canal Quay, Dublin 2, Ireland.
Research Institute for Fragrance Materials, Woodcliff Lake, NJ 07677, United States. Electronic address:
Unilever, Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Beds MK44 1LQ, United Kingdom.
Givaudan International S.A., 5 Chemin de la Parfumerie, CH1214, Vernier, Switzerland.
SH Robison Consulting, LLC, P.O. Box 688, Milford, OH 45150, United States.
The Procter and Gamble Company, Mason Business Center, 8700 Mason Montgomery Rd, Mason, OH 45040, United States.
B-Safe Toxicology Consulting, 31 Hayway, Rushden, Northants, NN10 6AG, United Kingdom.
Firmenich Inc., Post Office Box 5880, Princeton, NJ 08543, USA.
The Procter and Gamble Company, Central Product Safety, P&G Technical Centres Ltd., Whitehall Lane, Egham, Surrey TW20 9NW, United Kingdom.


In order to accurately assess aggregate exposure to a fragrance material in consumers, data are needed on consumer habits and practices, as well as the concentration of the fragrance material in those products. The present study describes the development of Phase 2 Creme RIFM model by expanding the previously developed Phase 1 model to include an additional six product types. Using subject-matching algorithms, the subjects in the Phase 1 Creme RIFM database were paired with subjects in the SUPERB and BodyCare surveys based on age and gender. Consumption of the additional products was simulated to create a seven day diary allowing full data integration in a consistent format. The inhalation route was also included for air care and other products where a fraction of product used is inhaled, derived from the RIFM 2-box model. The expansion of the Phase 1 Creme RIFM model has resulted in a more extensive and refined model, which covers a broader range of product categories and now, includes all relevant routes of exposure. An evaluation of the performance of the model has been carried out in an accompanying publication to this one.


Aggregate exposure; Cosmetics; Database; Fragrance ingredients; Habits and practices; Personal care

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