Copper-Catalyzed Cross-Dehydrogenative N2-Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N-Amidoalkylation of NH-1,2,3-Triazoles

Xiaocong Deng; Xue Lei; Gang Nie; Lihui Jia; Yuanxiang Li; Yunfeng Chen

doi:10.1021/acs.joc.7b00752

Copper-Catalyzed Cross-Dehydrogenative N²-Coupling of NH-1,2,3-Triazoles with N,N -Dialkylamides: N-Amidoalkylation of NH-1,2,3-Triazoles

J Org Chem. 2017 Jun 16;82(12):6163-6171. doi: 10.1021/acs.joc.7b00752. Epub 2017 Jun 7.

Authors

Xiaocong Deng¹, Xue Lei¹, Gang Nie¹, Lihui Jia¹, Yuanxiang Li², Yunfeng Chen¹

Affiliations

¹ School of Chemistry and Environmental Engineering, Wuhan Institute of Technology , Wuhan 430073, People's Republic of China.
² College of Chemistry and Materials Engineering, Huaihua University , Huaihua 418008, People's Republic of China.

PMID: 28558242
DOI: 10.1021/acs.joc.7b00752

Abstract

An efficient copper-catalyzed C-N bond formation by N-H/C-H cross-dehydrogenative coupling (CDC) between NH-1,2,3-triazoles and N,N-dialkylamides has been developed. The method provided N-amidoalkylated 1,2,3-triazoles with moderate to high yields, and the reactions showed high N²-selectivities when 4,5-disubstituted NH-1,2,3-triazoles served as the substrates.

Publication types

Research Support, Non-U.S. Gov't