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Am J Med Genet A. 2017 May 30. doi: 10.1002/ajmg.a.38257. [Epub ahead of print]

Mandibulofacial dysostosis Bauru type: Refining the phenotype.

Author information

1
Department of Clinical Genetics, Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRCA/USP), Bauru, São Paulo, Brazil.
2
Department of Orthodontics, Hospital for Rehabilitation of Craniofacial Anomalies, Bauru Dental School, University of São Paulo (HRCA/USP), Bauru, São Paulo, Brazil.
3
Department of Orthodontics, Bauru Dental School, University of São Paulo, Bauru, São Paulo, Brazil.

Abstract

Mandibulofacial dysostosis (MFD) Bauru type (OMIM 604830) is a rare genetic condition characterized mainly by malar hypoplasia, orofacial cleft, and micrognathia. Here, we describe the clinical and radiographic sings of 13 individuals (12 female and 1 male) from eight unrelated kindreds with MFD Bauru type, including four previously reported cases, treated at the Hospital for Rehabilitation of Craniofacial Anomalies. The clinical phenotype was characterized by severe underdevelopment of mandible, midface hypoplasia, orofacial cleft, bitemporal narrowing, mild upper eyelid down slanting, high nasal bridge, thick and everted lower lip, minor ears abnormalities, and hearing loss. Radiographic aspects included downslanting of zygomatic arch, maxillary hypoplasia, microretrognathia, hypoplastic mandibular condyles, and ectopic external auditory canal. Recurrence was observed in two of eight families and the affected distribution pattern was compatible with autosomal dominant inheritance in one and autosomal recessive in another, indicating possible genetic heterogeneity for this condition. Clinical and radiographic findings in this report contribute to the delineation of this rare MFD.

KEYWORDS:

cone beam computed tomography; craniofacial anomalies; mandibulofacial dysostosis Bauru type; orofacial clefting

PMID:
28558149
DOI:
10.1002/ajmg.a.38257

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