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Biofactors. 1988 Oct;1(3):213-7.

Platelet-derived growth factor: a multifunctional regulator of normal and abnormal cell growth.

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Department of Medicine and Biological Chemistry, Jewish Hospital, Washington University Medical Center, St Louis, MO 63110.


Polypeptide growth factors, which are synthesized and secreted both by normal and transformed cells, have a multiplicity of roles in normal and abnormal cell growth. Platelet-derived growth factor (PDGF) is nearly identical to the transforming gene (oncogene) product of simian sarcoma virus p28v-sis. Binding of PDGF to high-affinity cell surface PDGF receptors stimulates the intrinsic autophosphorylating protein tyrosine kinase activity of these receptors and sets off a cascade of metabolic events. Among these events are induction of otherwise quiescent genes which regulate synthesis of transcriptional factors and thus are critical in cell division, differentiation and development.

[Indexed for MEDLINE]

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