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Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700019. Epub 2017 Jul 18.

Fasting serum hippuric acid is elevated after bilberry (Vaccinium myrtillus) consumption and associates with improvement of fasting glucose levels and insulin secretion in persons at high risk of developing type 2 diabetes.

Author information

1
Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
2
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
3
VTT Technical Research Centre of Finland, Espoo, Finland.
4
Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Finland.
5
Clinical Nutrition and Obesity Center, Kuopio University Hospital, Finland.
6
School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
7
LC-MS Metabolomics Center, Biocenter Kuopio, Kuopio, Finland.
8
Research Unit, Kuopio University Hospital, Kuopio, Finland.
9
Center for Vascular Prevention, Danube-University Krems, Austria.
10
Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.

Abstract

SCOPE:

Urinary hippuric acid has been proposed as a biomarker for fruit, vegetable, and polyphenol consumption. We assessed how serum hippuric acid changes after a bilberry-enriched diet (BB; high anthocyanin intake) and another berry diet including strawberries, raspberries, and cloudberries (SRC; lower anthocyanin intake) and how these changes associate with insulin and glucose metabolism.

METHODS AND RESULTS:

Hippuric acid was measured with LC-QTOF-MS metabolite profiling analysis from fasting serum samples at baseline and after an 8-week intervention in 47 individuals with features of the metabolic syndrome who were randomized to either a BB diet (n = 15), an SRC diet (n = 20) or a control diet (n = 12). Fasting serum hippuric acid increased significantly (3.5-fold, p = 0.001) only in the BB group and correlated with changes in fasting plasma glucose concentration (r = -0.54, p < 0.05) and insulin secretion (r = 0.59, p < 0.05). These associations were confirmed in the Finnish Diabetes Prevention Study (n = 198).

CONCLUSION:

Fasting serum hippuric acid is increased after consumption of anthocyanin-rich bilberries, and may contribute to the beneficial effect of bilberry consumption through its associations with better glycemic control and β-cell function.

KEYWORDS:

Bilberry; Glucose metabolism; Hippuric acid; LC-MS; Vaccinium myrtillus

PMID:
28556578
DOI:
10.1002/mnfr.201700019
[Indexed for MEDLINE]

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