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Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700139. Epub 2017 Jul 20.

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice.

Author information

1
Major in Biomodulation, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
2
Department of Food Science and Nutrition, Hallym University, Chuncheon, Republic of Korea.
3
Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, Republic of Korea.
4
Chemical Biology Research Center and World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Republic of Korea.
5
Program in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Massachusetts Medical School, Worcester, MA, USA.

Abstract

SCOPE:

Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).

METHODS AND RESULTS:

Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 μM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines.

CONCLUSION:

These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.

KEYWORDS:

AMP-activated protein kinase; Adipocyte; Adipose tissue inflammation; Gingerenone A; Obesity

PMID:
28556482
PMCID:
PMC5947313
DOI:
10.1002/mnfr.201700139
[Indexed for MEDLINE]
Free PMC Article

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