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J Magn Reson Imaging. 2018 Feb;47(2):433-438. doi: 10.1002/jmri.25764. Epub 2017 May 26.

Dose-dependence of transient respiratory motion artifacts on gadoxetic acid-enhanced arterial phase MR images.

Author information

1
Department of Radiology, University of Yamanashi, Shimokato, Chuo-shi, Yamanashi, Japan.
2
Department of Diagnostic Radiology, Yamane, Hidaka-shi, Saitama Medical University International Medical Center, Saitama, Japan.

Abstract

PURPOSE:

To compare the occurrence of transient respiratory motion (TM) artifacts between 0.05 mmol/kg and 0.025 mmol/kg gadoxetic-acid on arterial phase MRI intra-individually for evaluating dose-dependence of gadoxetic acid.

MATERIALS AND METHODS:

This retrospective study involved 91 patients who underwent dynamic MRI at 1.5T at different times, one time with 0.05 mmol/kg and the other 0.025 mmol/kg gadoxetic-acid. Examinations with 0.05 mmol/kg totaled 91 scans, and examinations with 0.025 mmol/kg totaled 375 scans (due to multiple exams for several patients). The scan with 0.025 mmol/kg closest in time to the 0.05 mmol/kg scan was selected to minimize temporal effects. Two radiologists graded TM artifacts in the arterial phase images using a four-point scale: no, mild, moderate, and severe artifacts. Results were compared between the two protocols (0.05 mmol/kg versus all 0.025 mmol/kg and 0.05 mmol/kg versus selected 0.025 mmol/kg), and the odds ratio for moderate-to-severe artifacts was calculated.

RESULTS:

Significantly more TM artifacts were observed in the double dose (16/91 [17%]) scans compared with either all (17/375 [4%]; P < 0.01) or selected (3/91 [3%]; P = 0.01) standard dose scans. The odds ratio of the moderate-to-severe artifacts with the higher dose was 4.99-5.33.

CONCLUSION:

There appears to be dose-dependence of gadoxetic-acid and the occurrence of TM artifacts.

LEVEL OF EVIDENCE:

3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:433-438.

KEYWORDS:

arterial phase image; dose dependence; gadoxetic acid; magnetic resonance imaging; transient motion artifact

PMID:
28556388
DOI:
10.1002/jmri.25764

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