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Equine Vet J. 2018 Jan;50(1):34-40. doi: 10.1111/evj.12706. Epub 2017 Jul 12.

Comparison of aloe vera and omeprazole in the treatment of equine gastric ulcer syndrome.

Author information

1
School of Animal and Veterinary Science, Adelaide, South Australia, Australia.

Abstract

BACKGROUND:

Anecdotally, aloe vera is used to treat gastric ulceration, although no studies have yet investigated its efficacy in horses.

OBJECTIVES:

To test the hypothesis that aloe vera would be noninferior to omeprazole in the treatment of equine gastric ulcer syndrome.

STUDY DESIGN:

Randomised, blinded clinical trial.

METHODS:

Forty horses with grade ≥2 lesions of the squamous and/or glandular mucosa were randomly assigned to one of two groups. Horses received either aloe vera inner leaf gel (17.6 mg/kg bwt) b.i.d. or omeprazole (4 mg/kg bwt) s.i.d. for approximately 28 days, after which a repeat gastroscopic examination was performed to determine disease resolution. Horses with persistent lesions were offered a further 28 days of treatment with omeprazole (4 mg/kg bwt s.i.d.) and were re-examined on completion of treatment.

RESULTS:

Efficacy analyses were based on 39 horses that completed the trial. Equine squamous gastric disease (ESGD) was observed in 38 horses; improvement and healing rates in these horses were 56% and 17%, respectively, in the aloe vera group, and 85% and 75%, respectively, in the omeprazole group. Healing was less likely to occur in horses with prolonged gastric emptying. Equine glandular gastric disease (EGGD) was less common than ESGD (n = 14) and numbers were too small to perform meaningful statistical analyses. The hypothesis that aloe vera would be noninferior to omeprazole was not supported.

MAIN LIMITATIONS:

No placebo control group was included. Limited numbers preclude any comment on the efficacy of aloe vera in the treatment of EGGD.

CONCLUSIONS:

Treatment with aloe vera was inferior to treatment with omeprazole.

KEYWORDS:

equine gastric ulcer syndrome (EGUS); equine glandular gastric disease (EGGD); equine squamous gastric disease (ESGD); horse

PMID:
28555939
DOI:
10.1111/evj.12706
[Indexed for MEDLINE]

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