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Pathol Res Pract. 2017 Jul;213(7):854-856. doi: 10.1016/j.prp.2017.01.020. Epub 2017 Jan 28.

Evaluation of the presence of Epstein-Barr virus (EBV) in Iranian patients with thyroid papillary carcinoma.

Author information

1
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Medical Virology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: maryamhomayoni@gmail.com.
2
Department of Medical Virology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: ArabzadehAli1956@yahoo.com.
3
Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: fnili@yahoo.com.
4
Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: f-razi@tums.ac.ir.
5
Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: amolimm@tums.ac.ir.

Abstract

BACKGROUND AND PURPOSE:

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. EBV is one of the most important viruses related to different types of malignancies. This study investigated the relationship between EBV and papillary thyroid carcinoma.

MATERIAL AND METHODS:

In this study the presence of Epstein-Barr Nuclear Antigen 1 (EBNA1) gene in papillary thyroid carcinoma tissues were examined by nested-PCR method. Paraffin-embedded tissues (N=41) blocks of thyroid cancer were used. DNA was extracted from all samples and then samples were evaluated for the presence of EBV gene.

RESULTS:

In 41 samples, EBNA1 was detected in 65.8% of patients with papillary thyroid carcinoma which was significantly higher in younger ages.

CONCLUSION:

The significant presence of EBV genome in papillary thyroid carcinoma suggests that this virus may play a role in this cancer especially in younger ages. As a result, monitoring of patients with EBV latent infection for PTC can be very important.

KEYWORDS:

Epstein-Barr virus; Papillary thyroid carcinoma; Polymerase Chain Reaction

PMID:
28554750
DOI:
10.1016/j.prp.2017.01.020
[Indexed for MEDLINE]

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