Format

Send to

Choose Destination
Curr Opin Pharmacol. 2017 Aug;35:30-39. doi: 10.1016/j.coph.2017.05.002. Epub 2017 May 26.

The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO.

Author information

1
Department of Experimental Medicine, University of Perugia, 06132 Perugia, Italy.
2
Department of Medicine, Verona University Hospital, 37134 Verona, Italy.
3
Department of Medicine, Verona University Hospital, 37134 Verona, Italy. Electronic address: vincenzo.bronte@univr.it.

Abstract

Some enzymes degrading amino acids have evolved in mammals to dampen immune responses and maintain peripheral tolerance. The enzymes metabolizing l-arginine and l-tryptophan are particularly powerful, contributing to restrain immunity towards fetal tissues and establish neonatal tolerance. Solid tumors can hijack these formidable pathways to construct a microenvironment highly unfavorable to anti-tumor T lymphocytes able to recognize them, one of mechanisms for their immune evasion. In this review, we analyze emerging concepts in the cross-talk between cells expressing these enzymes, their immune regulatory functions and pharmacological approaches that can target them to enhance cancer immunotherapy.

PMID:
28554057
DOI:
10.1016/j.coph.2017.05.002
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center