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J Biol Rhythms. 2017 Jun;32(3):222-236. doi: 10.1177/0748730417704766. Epub 2017 May 29.

Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus.

Author information

1
Department of Biology, The Johns Hopkins University, Baltimore, Maryland.
2
Department of Biology, Stanford University School of Medicine, Stanford, California.
3
1. Section on Light and Circadian Rhythms (SLCR), National Institute of Mental Health, National Institute of Health, Bethesda, MD 20892.
4
The Solomon Snyder-Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland.
5
Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California.
6
Howard Hughes Medical, Institute, Stanford University School of Medicine, Stanford, California.
7
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut.

Abstract

Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the active portions of the day and period lengthening following a 15-minute phase-delaying light pulse. These data identify C1QL3 as a signaling molecule that is highly expressed in SCN neurons, where it contributes to the formation and/or maintenance of glutamatergic synapses and plays a role in circadian behaviors, which may include circadian aftereffects.

KEYWORDS:

C1q-like; C1ql; C1ql3; SCN; aftereffects; circadian; rhythms; suprachiasmatic nucleus; synapse

PMID:
28553739
PMCID:
PMC5664174
DOI:
10.1177/0748730417704766
[Indexed for MEDLINE]
Free PMC Article

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