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J Funct Foods. 2016 Dec;27:84-94. doi: 10.1016/j.jff.2016.08.044. Epub 2016 Sep 16.

Efficacy comparison of lyophilised black raspberries and combination of celecoxib and PBIT in prevention of carcinogen-induced oesophageal cancer in rats.

Author information

1
Division of Medical Oncology, Department of Internal Medicine, 410 West 12 Ave.
2
The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, The Ohio State University, 460 West 10 Ave., Columbus, Ohio 43210, USA.
3
Department of Food Science and Technology, 2015 Fyffe Road.
4
Center for Biostatistics, 1800 Cannon Drive.

Abstract

The objective of this study was to compare the efficacy and mechanism of lyophilized black raspberries (BRB) versus the combination of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT), a selective inducible nitric oxide synthase (iNOS) inhibitor in inhibition of carcinogen-induced esophageal squamous cell carcinoma in rats. Our data indicated that tumor multiplicity and histologic grade of esophageal precancerous lesions were reduced in animals fed BRB compared to those fed celecoxib + PBIT. The mechanistic studies showed that BRB and its major anthocyanin suppressed cell proliferation and oncogenic signaling. Our findings demonstrated that dietary BRB is superior to the combination of two pharmaceutical drugs in esophageal cancer prevention. These observations suggest the potential value of translational studies using BRB food products for esophageal cancer prevention in humans, particularly those with high-risk premalignant lesions.

KEYWORDS:

anthocyanin; black raspberries; cancer prevention; esophageal cancer

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