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Front Immunol. 2017 May 12;8:548. doi: 10.3389/fimmu.2017.00548. eCollection 2017.

Detrimental Impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and Immune Homeostasis: An Overview.

Daïen CI1,2,3, Pinget GV1,2, Tan JK4, Macia L1,2,4.

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Nutritional Immunometabolism Node Laboratory, Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
Institut de génétique moléculaire de Montpellier, UMR5535, Montpellier University, Montpellier, France.
Infection and Immunity Program, Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.


Dietary fibers are non-digestible polysaccharides functionally known as microbiota-accessible carbohydrates (MACs), present in inadequate amounts in the Western diet. MACs are a main source of energy for gut bacteria so the abundance and variety of MACs can modulate gut microbial composition and function. This, in turn, impacts host immunity and health. In preclinical studies, MAC-deprived diet and disruption of gut homeostasis aggravate the development of inflammatory diseases, such as allergies, infections, and autoimmune diseases. The present review provides a synopsis on the impact of a low-MAC diet on gut homeostasis or, more specifically, on gut microbiota, gut epithelium, and immune cells.


dietary fiber; epithelium; gut barrier; gut homeostasis; gut microbiota; immunity; microbiota-accessible carbohydrates

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