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Clin Interv Aging. 2017 May 15;12:815-822. doi: 10.2147/CIA.S134605. eCollection 2017.

Anti-amyloid aggregation activity of novel carotenoids: implications for Alzheimer's drug discovery.

Author information

1
Center for Biodiversity and Drug Discovery, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama.
2
Department of Biotechnology, Acharya Nagarjuna University, Guntur, India.
3
Center for Molecular and Cellular Biology of Diseases, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama.
4
Department of Biotechnology, Sir M Visvesvaraya Institute of Technology, Bangalore, India.
5
Department of Biochemistry, College of Natural, Exact Sciences and Technology, University of Panama, Panama, Republic of Panama.
6
Center for Neuroscience, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Republic of Panama.

Abstract

Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals present mainly in fruits and vegetables with reported benefits for human health. In this research, the anti-amyloidogenic activity of three carotenoids, cryptocapsin, cryptocapsin-5,6-epoxide, and zeaxanthin, was assessed. Cryptocapsin showed the highest bioactivity, while cryptocapsin-5,6-epoxide and zeaxanthin exhibited similar activity on anti-aggregation assays. Molecular modeling analysis revealed that the evaluated carotenoids might follow two mechanisms for inhibiting Aβ aggregation: by preventing the formation of the fibril and through disruption of the Aβ aggregates. Our studies provided evidence that cryptocapsin, cryptocapsin-5,6-epoxide, and zeaxanthin have anti-amyloidogenic potential and could be used for prevention and treatment of AD.

KEYWORDS:

6-epoxide; Alzheimer’s disease; aging; anti-amyloidogenic activity; cryptocapsin; cryptocapsin-5; zeaxanthin

PMID:
28553090
PMCID:
PMC5440000
DOI:
10.2147/CIA.S134605
[Indexed for MEDLINE]
Free PMC Article

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