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Exp Gerontol. 2017 Sep;95:141-147. doi: 10.1016/j.exger.2017.05.019. Epub 2017 May 25.

Leisure-time physical activity and leukocyte telomere length among older women.

Author information

1
Division of Epidemiology, Family Medicine and Public Health, University of California, San Diego School of Medicine, 9500 Gilman Drive #0725, La Jolla, CA 92093, USA. Electronic address: ahshadya@ucsd.edu.
2
Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY 14228, USA.
3
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA.
4
Department of Epidemiology, University of Washington, Seattle, WA 98105, USA.
5
Division of Biostatistics and Study Methodology, Center for Translational Science, George Washington University and Children's National Medical Center, 2121 I St NW, Washington, D.C. 20052, USA.
6
Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32611, USA.
7
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 420 E Superior St., Chicago, IL 60611, USA.
8
Division of Epidemiology, San Diego State University Graduate School of Public Health, 5500 Campanile Drive, San Diego, CA 92182, USA.
9
Department of Psychology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA.
10
Division of Biostatistics and Bioinformatics, Family Medicine and Public Health, University of California, San Diego School of Medicine, 9500 Gilman Drive #0725, La Jolla, CA 92093, USA.
11
Division of Epidemiology, Family Medicine and Public Health, University of California, San Diego School of Medicine, 9500 Gilman Drive #0725, La Jolla, CA 92093, USA.

Abstract

BACKGROUND:

Shortened leukocyte telomere length (LTL), a purported marker of cellular aging, is associated with morbidity and mortality. However, the association of physical activity, a modifiable lifestyle behavior, with LTL has not been adequately studied among older adults.

METHODS:

In this cross-sectional study, we examined associations of various intensity levels of leisure-time physical activity with LTL among 1476 older white and African American women from the Women's Health Initiative Objective Physical Activity and Cardiovascular Health study. Self-reported physical activity was assessed by questionnaire, and LTL was measured by Southern blot. The association between physical activity and LTL was evaluated using multiple linear regression models adjusted for demographic characteristics, lifestyle behaviors, and health-related variables.

RESULTS:

Women were on average aged 79.2 (standard deviation 6.7) years old. In the final model adjusted for age, race/ethnicity, education, marital status, smoking, alcohol, body mass index, a history of chronic diseases, and hormone therapy use, LTL was on average 110 (95% confidence interval, 20-190) base pairs longer among women in the highest (≥17.00MET-hours/week) compared with the lowest (<1.25MET-hours/week) level of total leisure-time physical activity (P for trend=0.02). Higher levels of moderate-to-vigorous physical activity (P for trend=0.04) and faster walking speed (P for trend=0.03) were also associated with longer LTL in the fully-adjusted models.

CONCLUSION:

Older women participating in greater amounts of total leisure-time physical activity and moderate-to-vigorous physical activity had longer LTL.

KEYWORDS:

Leukocyte telomere length; MVPA; Older adults; Physical activity; Walking; Women

PMID:
28552815
PMCID:
PMC5530759
DOI:
10.1016/j.exger.2017.05.019
[Indexed for MEDLINE]
Free PMC Article

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