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Can J Diabetes. 2017 Aug;41(4):439-447. doi: 10.1016/j.jcjd.2017.02.002. Epub 2017 May 25.

The Gut Microbiota as a Mediator of Metabolic Benefits after Bariatric Surgery.

Author information

1
Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Quebec City, Quebec, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
2
Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada.
3
Department of Biochemistry and Biomedical Sciences and Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
4
Department of Medicine, Faculty of Medicine, Cardiology Axis of the Québec Heart and Lung Institute, Quebec City, Quebec, Canada; Institute of Nutrition and Functional Foods, Laval University, Quebec City, Quebec, Canada. Electronic address: andre.marette@criucpq.ulaval.ca.

Abstract

Bariatric surgery is based on major anatomic rearrangements in the gastrointestinal tract that coincide with functional and taxonomic changes in gut microbial communities. These alterations in gut anatomy and in the microbiota are associated with early resolution of obesity-related impairment of glycemic control and are marked weight loss in the long term. Moreover, altered bile acid metabolism has been implicated in the control of energy homeostasis, emerging as a pivotal orchestrator in the gut microbiota-mediated effects of bariatric surgery. In this review, we summarize the growing body of evidence linking changes in the gut microbiota to the metabolic benefits of bariatric surgery and discuss the potential mechanisms involved.

KEYWORDS:

Roux-en-Y; anse en Y de Roux; gastrectomie longitudinale; gastric bypass; glycemic control and bile acids; pontage gastrique; régulation de la glycémie et acides biliaires; sleeve gastrectomy

PMID:
28552651
DOI:
10.1016/j.jcjd.2017.02.002
[Indexed for MEDLINE]

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