Format

Send to

Choose Destination
Brain Struct Funct. 2017 Dec;222(9):3973-3990. doi: 10.1007/s00429-017-1443-x. Epub 2017 May 27.

Large-scale functional neural network correlates of response inhibition: an fMRI meta-analysis.

Zhang R1,2, Geng X1,2,3, Lee TMC4,5,6,7.

Author information

1
Laboratory of Neuropsychology, The University of Hong Kong, Rm 656, Jockey Club Tower, Pokfulam Road, Hong Kong, Hong Kong.
2
Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Hong Kong, Hong Kong.
3
The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong.
4
Laboratory of Neuropsychology, The University of Hong Kong, Rm 656, Jockey Club Tower, Pokfulam Road, Hong Kong, Hong Kong. tmclee@hku.hk.
5
Laboratory of Cognitive Affective Neuroscience, The University of Hong Kong, Hong Kong, Hong Kong. tmclee@hku.hk.
6
The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong. tmclee@hku.hk.
7
Institute of Clinical Neuropsychology, The University of Hong Kong, Hong Kong, Hong Kong. tmclee@hku.hk.

Abstract

An influential hypothesis from the last decade proposed that regions within the right inferior frontal cortex of the human brain were dedicated to supporting response inhibition. There is growing evidence, however, to support an alternative model, which proposes that neural areas associated with specific inhibitory control tasks co-exist as common network mechanisms, supporting diverse cognitive processes. This meta-analysis of 225 studies comprising 323 experiments examined the common and distinct neural correlates of cognitive processes for response inhibition, namely interference resolution, action withholding, and action cancellation. Activation coordinates for each subcategory were extracted using multilevel kernel density analysis (MKDA). The extracted activity patterns were then mapped onto the brain functional network atlas to derive the common (i.e., process-general) and distinct (i.e., domain-oriented) neural network correlates of these processes. Independent of the task types, activation of the right hemispheric regions (inferior frontal gyrus, insula, median cingulate, and paracingulate gyri) and superior parietal gyrus was common across the cognitive processes studied. Mapping the activation patterns to a brain functional network atlas revealed that the fronto-parietal and ventral attention networks were the core neural systems that were commonly engaged in different processes of response inhibition. Subtraction analyses elucidated the distinct neural substrates of interference resolution, action withholding, and action cancellation, revealing stronger activation in the ventral attention network for interference resolution than action inhibition. On the other hand, action withholding/cancellation primarily engaged the fronto-striatal circuit. Overall, our results suggest that response inhibition is a multidimensional cognitive process involving multiple neural regions and networks for coordinating optimal performance. This finding has significant implications for the understanding and assessment of response inhibition.

KEYWORDS:

Action restrain; Interference resolution; Meta-analysis; Multilevel kernel density analysis; fMRI

PMID:
28551777
PMCID:
PMC5686258
DOI:
10.1007/s00429-017-1443-x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center