Format

Send to

Choose Destination
Clin Oral Investig. 2017 Jul;21(6):1913-1927. doi: 10.1007/s00784-017-2133-z. Epub 2017 May 27.

Use of platelet-rich fibrin in regenerative dentistry: a systematic review.

Author information

1
College of Dental Medicine, Department of Periodontology, Nova Southeastern University, Fort Lauderdale, FL, USA. richard.miron@zmk.unibe.ch.
2
Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USA. richard.miron@zmk.unibe.ch.
3
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
4
Pikos Institute, Tampa Bay, FL, USA.
5
College of Dental Medicine, Department of Periodontology, Nova Southeastern University, Fort Lauderdale, FL, USA.
6
Department of Periodontology, Georgia University, Athens, GA, USA.
7
Goldstein Garber & Salama, Atlanta, GA, USA.
8
International Academy of Dental Implantology, San Diego, CA, USA.
9
Department of Periodontology, Laval University, Quebec City, Canada.
10
Department of Cranio-Maxillofacial Surgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
11
Department of Oral Surgery, Clinical Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
12
West Bowmanville Dental, Bowmanville, Ontario, Canada.
13
Department of Oral Implantology, University of Wuhan, Wuhan, China.
14
Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, MI, USA.
15
Laboratory for Research of the Musculoskeletal System, KAT Hospital, School of Medicine, National and Kapodistrian, University of Athens, Athens, Greece.
16
Oral Surgery Department, University Federico II Naples, Naples, Italy.
17
Periodontology and Implantology, Beausoleil, France.
18
Periodontology and Implantology, Marseille, France.
19
Department of Advanced Periodontics, USC School of Dentistry, Los Angeles, CA, USA.
20
Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
21
FORM, Frankfurt Oral Regenerative Medicine, Clinic for Maxillofacial and Plastic Surgery, Johann Wolfgang Goethe University, Frankfurt am Main, Germany.
22
Pain Clinic, Nice, France.

Abstract

OBJECTIVES:

Research across many fields of medicine now points towards the clinical advantages of combining regenerative procedures with platelet-rich fibrin (PRF). This systematic review aimed to gather the extensive number of articles published to date on PRF in the dental field to better understand the clinical procedures where PRF may be utilized to enhance tissue/bone formation.

MATERIALS AND METHODS:

Manuscripts were searched systematically until May 2016 and separated into the following categories: intrabony and furcation defect regeneration, extraction socket management, sinus lifting procedures, gingival recession treatment, and guided bone regeneration (GBR) including horizontal/vertical bone augmentation procedures. Only human randomized clinical trials were included for assessment.

RESULTS:

In total, 35 articles were selected and divided accordingly (kappa = 0.94). Overall, the use of PRF has been most investigated in periodontology for the treatment of periodontal intrabony defects and gingival recessions where the majority of studies have demonstrated favorable results in soft tissue management and repair. Little to no randomized clinical trials were found for extraction socket management although PRF has been shown to significantly decrease by tenfold dry sockets of third molars. Very little to no data was available directly investigating the effects of PRF on new bone formation in GBR, horizontal/vertical bone augmentation procedures, treatment of peri-implantitis, and sinus lifting procedures.

CONCLUSIONS:

Much investigation now supports the use of PRF for periodontal and soft tissue repair. Despite this, there remains a lack of well-conducted studies demonstrating convincingly the role of PRF during hard tissue bone regeneration. Future human randomized clinical studies evaluating the use of PRF on bone formation thus remain necessary.

CLINICAL RELEVANCE:

PRF was shown to improve soft tissue generation and limit dimensional changes post-extraction, with little available data to date supporting its use in GBR.

KEYWORDS:

Bone augmentation; Platelet-rich fibrin; Soft tissue regeneration; Tissue regeneration

PMID:
28551729
DOI:
10.1007/s00784-017-2133-z
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center