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Clin Biochem. 2017 Nov;50(16-17):972-976. doi: 10.1016/j.clinbiochem.2017.05.011. Epub 2017 May 25.

Association between thyroid hormones and TRAIL.

Author information

1
Department of Medical Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume, 34100 Trieste, Italy. Electronic address: stella.bernardi@asuits.sanita.fvg.it.
2
Department of Medical Sciences, University of Trieste, Cattinara Teaching Hospital, Strada di Fiume, 34100 Trieste, Italy.
3
Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", 34100 Trieste, Italy.
4
Department of Laboratory Medicine, ASUITS, Maggiore Hospital, Via Stuparich, 34100 Trieste, Italy.
5
Department of Morphology, Surgery and Experimental Medicine and LTTA Centre, University of Ferrara, 44100 Ferrara, Italy.

Abstract

INTRODUCTION:

Recent studies suggest that a circulating protein called TRAIL (TNF-related apoptosis-inducing ligand) might have a role in the regulation of body weight and metabolism. Interestingly, thyroid hormones seem to increase TRAIL tissue expression. This study aimed at evaluating whether overt thyroid disorders affected circulating TRAIL levels.

METHODS:

TRAIL circulating levels were measured in euthyroid, hyperthyroid, and hypothyroid patients before and after thyroid function normalization. Univariate and multivariate analyses were performed to evaluate the correlation between thyroid hormones and TRAIL. Then, the stimulatory effect of both triiodothyronine (T3) and thyroxine (T4) on TRAIL was evaluated in vitro on peripheral blood mononuclear cells.

RESULTS:

Circulating levels of TRAIL significantly increased in hyperthyroid and decreased in hypothyroid patients as compared to controls. Once thyroid function was restored, TRAIL levels normalized. There was an independent association between TRAIL and both fT3 and fT4. Consistent with these findings, T3 and T4 stimulated TRAIL release in vitro.

CONCLUSION:

Here we show that thyroid hormones are associated with TRAIL expression in vivo and stimulate TRAIL expression in vitro. Given the overlap between the metabolic effects of thyroid hormones and TRAIL, this work sheds light on the possibility that TRAIL might be one of the molecules mediating thyroid hormones peripheral effects.

[Indexed for MEDLINE]
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