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Trends Microbiol. 2017 Sep;25(9):729-740. doi: 10.1016/j.tim.2017.04.006. Epub 2017 May 24.

'Omic' Approaches to Study Uropathogenic Escherichia coli Virulence.

Author information

1
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland 4072, Australia.
2
GSK Vaccines Institute for Global Health S.r.l., 53100, Siena, Italy.
3
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia; Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address: m.schembri@uq.edu.au.

Abstract

Uropathogenic Escherichia coli (UPEC) is a pathogen of major significance to global human health and is strongly associated with rapidly increasing antibiotic resistance. UPEC is the primary cause of urinary tract infection (UTI), a disease that involves a complicated pathogenic pathway of extracellular and intracellular lifestyles during interaction with the host. The application of multiple 'omic' technologies, including genomics, transcriptomics, proteomics, and metabolomics, has provided enormous knowledge to our understanding of UPEC biology. Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection.

KEYWORDS:

UPEC; genomics; metabolomics; proteomics; transcriptomics; virulence

PMID:
28550944
DOI:
10.1016/j.tim.2017.04.006
[Indexed for MEDLINE]

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