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Front Med. 2017 Sep;11(3):440-444. doi: 10.1007/s11684-017-0523-x. Epub 2017 May 27.

Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET/CT.

Author information

1
Department of Haematology, Qilu Hospital, Shandong University, Jinan, 250012, China.
2
Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
3
PET/CT Center, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
4
Department of Hepatobiliary Surgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
5
Department of Haematology, Qingdao University Medical College, Qingdao, 266071, China.
6
Department of Haematology, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China. renjiedi@126.com.
7
Department of Haematology, Qilu Hospital, Shandong University, Jinan, 250012, China. junpeng88@sina.com.cn.

Abstract

Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia. As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lytic lesions. In this paper, we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain, fever, fatigue, emaciation, and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion, multiple soft tissue neoplasms with high 18F-FDG uptake, and lytic bone lesions. Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker. For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acute myeloid leukemia was made, although the type (de novo or blast crisis) remained unclear.

KEYWORDS:

Philadelphia chromosome; acute myeloid leukemia; mass; osteolysis; positron emission tomography

PMID:
28550639
DOI:
10.1007/s11684-017-0523-x
[Indexed for MEDLINE]

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