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Eur J Cardiothorac Surg. 2017 Nov 1;52(5):993-994. doi: 10.1093/ejcts/ezx165.

Thoracic aortitis and aortic dissection following pegfilgrastim administration.

Author information

1
Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
2
Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital, Kobe, Japan.
3
Department of Radiology, Kobe City Medical Center General Hospital, Kobe, Japan.

Abstract

The patient was a 67-year-old woman with a history of advanced lung adenocarcinoma. Eight days after pegfilgrastim administration, her computed tomography scan revealed thickened bilateral common carotid arteries and thoracic aorta, which led to the diagnosis of pegfilgrastim-associated aortitis. Thirty-six days after pegfilgrastim administration, asymptomatic Stanford type B aortic dissection was detected. Her serum biomarker analysis suggested that interleukin-6 might be involved in the pathogenesis. Physicians should be aware of these adverse effects of filgrastim.

KEYWORDS:

Aortic dissection; Aortitis; Pegfilgrastim

PMID:
28549110
DOI:
10.1093/ejcts/ezx165
[Indexed for MEDLINE]

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