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Mol Oncol. 2017 Jul;11(7):755-769. doi: 10.1002/1878-0261.12083. Epub 2017 Jun 12.

EMT and MET: necessary or permissive for metastasis?

Author information

1
Center for Theoretical Biological Physics, Rice University, Houston, TX, USA.
2
Duke Cancer Institute & Department of Medicine, Duke University Medical Center, Durham, NC, USA.

Abstract

Epithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition (MET) have been suggested to play crucial roles in metastatic dissemination of carcinomas. These phenotypic transitions between states are not binary. Instead, carcinoma cells often exhibit a spectrum of epithelial/mesenchymal phenotype(s). While epithelial/mesenchymal plasticity has been observed preclinically and clinically, whether any of these phenotypic transitions are indispensable for metastatic outgrowth remains an unanswered question. Here, we focus on epithelial/mesenchymal plasticity in metastatic dissemination and propose alternative mechanisms for successful dissemination and metastases beyond the traditional EMT/MET view. We highlight multiple hypotheses that can help reconcile conflicting observations, and outline the next set of key questions that can offer valuable insights into mechanisms of metastasis in multiple tumor models.

KEYWORDS:

epithelial-to-mesenchymal transition; hybrid epithelial/mesenchymal; mesenchymal-to-epithelial transition; metastasis; phenotypic plasticity

PMID:
28548345
PMCID:
PMC5496498
DOI:
10.1002/1878-0261.12083
[Indexed for MEDLINE]
Free PMC Article

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