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J Med Virol. 2017 Oct;89(10):1714-1719. doi: 10.1002/jmv.24865. Epub 2017 Jul 6.

The possible role of CCR5Δ32 mutation in Crimean-Congo hemorrhagic fever infection.

Author information

1
Faculty of Medicine, Gaziosmanpasa University, Department of Medical Biology, Tokat, Turkey.
2
Faculty of Medicine, Hitit University, Department of Medical Genetics, Çorum, Turkey.
3
Faculty of Medicine, Gaziosmanpasa University, Department of Infectious Diseases and Clinical Microbiology, Tokat, Turkey.
4
Department of Infectious Diseases and Clinical Microbiology, Ankara Onkology Training & Research Hospital, Ankara, Turkey.
5
Department of Infectious Diseases and Clinical Microbiology, Samsun Training & Research Hospital, Ankara, Turkey.

Abstract

Crimean-Congo hemorrhagic fever infection (CCHF) is a viral zoonosis. The pathogenesis of this disease has not been established so far, however, cytokines account for its progression and outcome. The aim of the present study is to investigate the association between chemokine receptor 5 (CCR5) gene Δ32 mutation and pathogenity, severity, and mortality of CCHF. This case-control study included 133 CCHF patients diagnosed by detection of CCHV RNA positivity and 97 healthy control subjects. CCR5 gene Δ32 mutation analyzed by polymerase chain reaction (PCR) method. The results were compared by using SPSS 16.0 and WINPEPI software's. The genotype distribution and allele frequency of the CCR5Δ32 were statistically different between the patients and the control group (P = 0.017; OR: 4.98 95% CI = 1.65-14.99 and P = 0.019; OR:4.76 95%CI = 1.30-17.50, respectively). CCR5/CCR5 (W/W) genotype and W allele of CCR5 gene were more common in patient group than in controls. There was no significant difference in severe and mild cases with regard to genotype distribution and allele distribution of CCR5Δ32 mutation (P >0.05). These results suggest that the CCR5 gene and its product might play a role in the pathogenesis of CCHF disease. Future studies will help us to uncover the exact role of CCR5 in the pathogenesis and prognosis of CCHF and to treat the disease.

KEYWORDS:

Crimean-Congo hemorrhagic fever; chemokine receptor 5 gene; Δ32 mutation

PMID:
28547880
DOI:
10.1002/jmv.24865
[Indexed for MEDLINE]

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