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Diabetes Care. 2017 Aug;40(8):1002-1009. doi: 10.2337/dc16-1990. Epub 2017 May 25.

Factors Associated With Diabetes-Specific Health-Related Quality of Life in Youth With Type 1 Diabetes: The Global TEENs Study.

Author information

1
Baylor College of Medicine/Texas Children's Hospital, Houston, TX bja@bcm.edu.
2
Joslin Diabetes Center, Boston, MA.
3
Sanofi, Paris, France.
4
Auf der Bult Kinder- und Jugendkrankenhaus, Hannover, Germany.
5
Institute for Endocrinology and Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
6
Hospital de Pediatria J.P. Garrahan, Buenos Aires, Argentina.
7
Sahlgrenska Academy, Gothenburg, Sweden.
8
NU Hospital Group, Uddevalla, Sweden.
9
National Children & Young People's Diabetes Network, London, U.K.
10
Jaeb Center for Health Research, Tampa, FL.
11
Atlanstat, Rezé, France.
12
Clinical and Experimental Endocrinology, UZ Gasthuisberg, University of Leuven, Leuven, Belgium.

Abstract

OBJECTIVE:

Our objective was to characterize diabetes-specific health-related quality of life (D-HRQOL) in a global sample of youth and young adults with type 1 diabetes (T1D) and to identify the main factors associated with quality of life.

RESEARCH DESIGN AND METHODS:

The TEENs study was an international, cross-sectional study of youth, 8-25 years of age, with T1D. Participants (N = 5,887) were seen in clinical sites in 20 countries across 5 continents enrolled for 3 predetermined age groups: 8-12, 13-18, and 19-25 years of age. To assess D-HRQOL, participants completed the PedsQL Diabetes Module 3.0 and were interviewed about family-related factors. Specifics about treatment regimen and self-management behaviors were collected from medical records.

RESULTS:

Across all age groups, females reported significantly lower D-HRQOL than did males. The 19-25-year age group reported the lowest D-HRQOL. Multivariate linear regression analyses revealed that D-HRQOL was significantly related to HbA1c; the lower the HbA1c, the better the D-HRQOL. Three diabetes-management behaviors were significantly related to better D-HRQOL: advanced methods used to measure food intake; more frequent daily blood glucose monitoring; and more days per week that youth had ≥30 min of physical activity.

CONCLUSIONS:

In all three age groups, the lower the HbA1c, the better the D-HRQOL, underscoring the strong association between better D-HRQOL and optimal glycemic control in a global sample of youth and young adults. Three diabetes-management behaviors were also related to optimal glycemic control, which represent potentially modifiable factors for clinical interventions to improve D-HRQOL as well as glycemic control.

PMID:
28546221
PMCID:
PMC5864137
DOI:
10.2337/dc16-1990
[Indexed for MEDLINE]
Free PMC Article

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