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J Diabetes Complications. 2017 Aug;31(8):1272-1274. doi: 10.1016/j.jdiacomp.2017.04.018. Epub 2017 Apr 19.

Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment.

Author information

1
Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain.
2
Fundació ACE, Barcelona Alzheimer Treatment & Research Center, Barcelona, Spain.
3
Institut de Recerca Vall d'Hebron, Universitat Autònoma de Barcelona (VHIR-UAB), Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas, Instituto de Salud Carlos III, Spain. Electronic address: rafael.simo@vhir.org.

Abstract

AIMS:

To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI).

METHODS:

A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included.

RESULTS:

The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p=0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia.

CONCLUSION:

T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.

PMID:
28545893
DOI:
10.1016/j.jdiacomp.2017.04.018
[Indexed for MEDLINE]

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