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J Chromatogr A. 2017 Jul 14;1506:93-100. doi: 10.1016/j.chroma.2017.05.001. Epub 2017 May 2.

Simultaneous on-line monitoring of propofol and sevoflurane in balanced anesthesia by direct resistive heating gas chromatography.

Author information

1
Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education of China, Zhejiang University, Hangzhou, Zhejiang, China.
2
Department of Anesthesia, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
3
Tongde hospital of Zhejiang province, Hangzhou, Zhejiang, China.
4
Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education of China, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: cnxingchen@zju.edu.cn.

Abstract

In balanced anesthesia, sevoflurane and propofol are often used in combination to achieve a better anesthetic effect. However, methods for on-line monitoring of concentrations of the two anesthetics in patients are still rare in clinical. This study proposed a non-invasive method utilizing a fast gas chromatograph combined with a surface acoustic wave sensor (Fast GC-SAW) to simultaneously on-line monitor sevoflurane and propofol in patients' exhaled gas. By using the direct resistive heating capillary column, the single detection time of Fast GC-SAW system was significantly shortened to 90s, as well as the size reduced to (40cm×30cm×20cm). Besides, in the calibration of sevoflurane, Fast GC-SAW system showed a good linear correlation (R2=0.9925, P<0.01) with gas chromatography-mass spectrometer (GC-MS), which ensured the reliability and accuracy of the Fast GC-SAW system. Finally, clinical experiments on patients under balanced anesthesia were conducted. The varied concentrations measured by Fast GC-SAW extraordinarily matched the clinical usages of these two anesthetics.

KEYWORDS:

Balanced anesthesia monitoring; Direct resistive heating; Fast gas chromatograph; Propofol; Sevoflurane; Surface acoustic wave

PMID:
28545733
DOI:
10.1016/j.chroma.2017.05.001
[Indexed for MEDLINE]

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