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Lipids Health Dis. 2017 May 25;16(1):97. doi: 10.1186/s12944-017-0486-6.

Emulsifying dietary fat modulates postprandial endotoxemia associated with chylomicronemia in obese men: a pilot randomized crossover study.

Author information

1
Univ-Lyon, CarMeN laboratory, INRA U1397, Inserm U1060, Université Claude Bernard Lyon 1, INSA Lyon, Charles Mérieux Medical School, FR-69600, Oullins, France.
2
Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA) and Centre Européen pour la Nutrition et la Santé (CENS), Pierre-Bénite, France.
3
The present address of Cécile Vors is: Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Pavillon des Services 2440 boulevard Hochelaga, Québec, G1V 0A6, Canada.
4
Laboratoire de Biochimie, Centre Hospitalier Lyon Sud, Pierre-Bénite, France.
5
Univ-Lyon, CarMeN laboratory, INRA U1397, Inserm U1060, Université Claude Bernard Lyon 1, INSA Lyon, Charles Mérieux Medical School, FR-69600, Oullins, France. marie-caroline.michalski@insa-lyon.fr.
6
Centre de Recherche en Nutrition Humaine Rhône-Alpes (CRNH-RA) and Centre Européen pour la Nutrition et la Santé (CENS), Pierre-Bénite, France. marie-caroline.michalski@insa-lyon.fr.

Abstract

BACKGROUND:

Postprandial hyperlipemia is recognized as a major cardio-metabolic risk factor, recently linked to the co-absorption of pro-inflammatory lipopolysaccharides with dietary lipids. This causes endotoxemia that is involved in the pathophysiology of obesity and insulin resistance, but to date the impact of food formulation is unknown. We tested a novel concept that endotoxin absorption can be modulated by fat emulsified structure in the meal, and potentially differently in obese vs. lean men.

METHODS:

In a randomized controlled crossover study, eight normal-weight and eight obese age-matched healthy men ingested two isocaloric, isolipidic breakfasts of identical composition including 40 g of milk fat that was emulsified or unemulsified. Plasma- and chylomicron-endotoxemia and chylomicron-triglycerides were measured during 8 h after breakfast ingestion.

RESULTS:

After emulsion consumption, parallel to an enhanced chylomicronemia, obese subjects presented an early and sharp increase in chylomicron-endotoxemia at 60 min (P time = 0.02), which was higher than (i) after spread fat in obese subjects (P < 0.05) and (ii) after both spread and emulsified fat in normal-weight subjects (P < 0.05). However in obese subjects, the iAUC of plasma endotoxemia over 8 h was lower after emulsion than after spread fat (P < 0.05) whereas in NW subjects such reduction of plasma LPS-iAUC was not observed (P = 0.67).

CONCLUSION:

This study provides initial evidence that optimizing fat structure in the meal can be part of a dietary strategy to lower the metabolic impact of postprandial endotoxemia in obese men.

TRIAL REGISTRATION:

Registered at ClinicalTrials.gov # NCT01249378 on July 13, 2010.

PMID:
28545546
PMCID:
PMC5445284
DOI:
10.1186/s12944-017-0486-6
[Indexed for MEDLINE]
Free PMC Article

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