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Molecules. 2017 May 23;22(6). pii: E855. doi: 10.3390/molecules22060855.

Phloroglucinols with Antioxidant Activities Isolated from Lysidice rhodostegia.

Author information

1
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. wuxf99@163.com.
2
National Institutes for Food and Drug Control, Beijing 100050, China. wuxf99@163.com.
3
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. annaleelin@imm.ac.cn.
4
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. liyong@imm.ac.cn.
5
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. lhn371102@126.com.
6
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. liuyunbao@imm.ac.cn.
7
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. huyoucai@imm.ac.cn.

Abstract

Two new phloroglucinols, lysidisides X and Y (1 and 2), and two known compounds, 2-(2-methylbutyryl)phloroglucinol 1-O-β-d-glucopyranoside (3) and (E)-resveratrol 3-(6″-galloyl)-O-β-d-glucopyranoside (4), have been isolated from the roots of Lysidice rhodostegia. The structures of 1 and 2 were elucidated primarily by NMR experiments. Their absolute configurations were deduced via circular dichroism (CD) data and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 exhibited significant antioxidative activities with IC50 values of 12.0 and 11.8 µM, respectively.

KEYWORDS:

Lysidice rhodostegia; antioxidative activity; electronic circular dichroism (ECD) calculation; phloroglucinol

PMID:
28545244
PMCID:
PMC6152794
DOI:
10.3390/molecules22060855
[Indexed for MEDLINE]
Free PMC Article

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