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Obesity (Silver Spring). 2017 Jun;25(6):997-1005. doi: 10.1002/oby.21833.

Inflammatory potential of diet, weight gain, and incidence of overweight/obesity: The SUN cohort.

Author information

1
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
2
Department of Cardiology, Complejo Hospitalario de Navarra, Pamplona, Spain.
3
IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
4
Servicio Navarro de Salud, Pamplona, Spain.
5
Ciber de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.
6
Centre for Nutrition Research, University of Navarra, Pamplona, Spain.
7
Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
8
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
9
Connecting Health Innovations LLC, Columbia, South Carolina, USA.
10
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Abstract

OBJECTIVE:

This study prospectively assessed the association of the inflammatory potential of a diet using the dietary inflammatory index (DII) with average yearly weight changes and incident overweight/obesity.

METHODS:

Seven thousand and twenty-seven university graduates with body mass index <25 from the Seguimiento Universidad de Navarra (SUN) cohort were followed up during a median of 8.1 years. The DII, a validated tool based on scientific evidence to appraise the relationship between dietary parameters and inflammatory biomarkers, was used. A validated food-frequency questionnaire was used to assess intake of total energy, food, and nutrients, from which DII scores were calculated at baseline and after 10 years of follow-up.

RESULTS:

After a median follow-up of 8.1 years, 1,433 incident cases of overweight or obesity were observed. Hazard ratios for overweight/obesity were calculated, including multivariable time-dependent Cox regression models with repeated measures of diet. The hazard ratio for subjects in the highest quartile (most pro-inflammatory diet) was 1.32 (95% confidence interval 1.08-1.60) compared with participants in the lowest quartile (most anti-inflammatory diet), with a significant linear dose-response relationship (P = 0.004). Consistently, increases in average yearly weight gains were significantly associated with proinflammatory diets.

CONCLUSIONS:

A proinflammatory diet was significantly associated with a higher annual weight gain and higher risk of developing new-onset overweight or obesity.

PMID:
28544794
DOI:
10.1002/oby.21833
[Indexed for MEDLINE]
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