Send to

Choose Destination
Skin Res Technol. 2018 Feb;24(1):26-30. doi: 10.1111/srt.12386. Epub 2017 May 24.

In vivo exfoliating efficacy of biodegradable beads and the correlation with user's satisfaction.

Author information

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.



By the end of 2017, non-biodegradable microbeads will be prohibited in USA, UK and Europe, due to their environmental issue. There are biodegradable beads available, but their effect on skin desquamation has not been evaluated yet. This study aimed to understand the skin renewal time, moisturizing effect and user's satisfaction of gel scrubs containing different exfoliating beads.


Gel scrubs, containing polyethylene, mannan or wax beads, were used in this study. The stratum corneum turnover time (SCTT) and skin hydration were evaluated by dansyl chloride staining technique and Corneometer® , respectively. The self-assessment was also performed after a 3-week home use trial.


The SCTTs of three different gel scrubs were not significantly different. A numerical increase in the skin hydration level was found in all groups. Satisfaction scores for the appearance and usability attributes were similar, but scores for improvement in the skin hydration and skin smoothness were higher in the gel scrubs with mannan or wax beads.


All three gel scrubs provided a similar effect on the SCTT and skin hydration, but gel scrubs with mannan or wax beads were more favorable. Thus, these two biodegradable exfoliating beads may be good substitutes in scrubbing products.


Corneometer®; dansyl chloride; exfoliating beads; gel scrubs; moisturizing effect; stratum corneum turnover time

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center