Thrombocytopenia Associated with Localized Scleroderma: Report of Four Pediatric Cases and Review of the Literature

Pediatr Dermatol. 2017 Jul;34(4):e174-e178. doi: 10.1111/pde.13159. Epub 2017 May 23.

Abstract

We report on four children with localized scleroderma (morphea) and thrombocytopenia. All four had the en coup de sabre subtype of morphea and had varying degrees of thrombocytopenia (8 × 109 /L to 120 × 109 /L). None of them had major bleeding manifestations, and thrombocytopenia resolved with treatment of morphea. (One patient was also given an injection of anti-D immunoglobulin.) We propose that thrombocytopenia associated with localized scleroderma is usually benign and requires no specific therapy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Child
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Male
  • Methotrexate / therapeutic use*
  • Platelet Count
  • Scleroderma, Localized / complications*
  • Scleroderma, Localized / drug therapy
  • Thrombocytopenia / complications*
  • Thrombocytopenia / drug therapy

Substances

  • Immunosuppressive Agents
  • Methotrexate