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J Pharm Pharmacol. 2017 Sep;69(9):1219-1229. doi: 10.1111/jphp.12748. Epub 2017 May 23.

Effect of aqueous extract and anthocyanins of calyces of Hibiscus sabdariffa (Malvaceae) in rats with adenine-induced chronic kidney disease.

Author information

1
Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al Khod, Oman.
2
ADINACO Research Group, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.
3
Department of Histology-Embryology, Faculty of Medicine, University of Trakya, Edirne, Turkey.
4
Department of Physiology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UAE.
5
Department of Analytical Chemistry, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic.
6
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, Hampshire, UK.

Abstract

OBJECTIVES:

The aim of this work was to assess the possible beneficial effects of aqueous extracts of Hibiscus sabdariffa L. calyces and anthocyanins isolated therefrom in an adenine-induced chronic kidney disease (CKD) model.

METHODS:

Rats were orally given, for 28 consecutive days, either adenine alone or together with either aqueous extract of H. sabdariffa calyces (5 and 10%) or anthocyanins (50, 100 and 200 mg/kg of anthocyanin concentrate). For comparative purposes, two groups of rats were given lisinopril (10 mg/kg).

KEY FINDINGS:

When either H. sabdariffa aqueous extract or the anthocyanins isolated from it was administered along with adenine, the adverse effects of adenine-induced CKD were significantly lessened, mostly in a dose-dependent manner. The positive effects were similar to those obtained by administration of lisinopril.

CONCLUSIONS:

The results obtained show that both H. sabdariffa and its anthocyanins could be considered as possible promising safe dietary agents that could be used to attenuate the progression of human CKD. This could have added significance as H. sabdariffa tea is widely consumed in many parts of Africa and Asia and is thus readily available.

KEYWORDS:

Hibiscus sabdariffa ; adenine; anthocyanins; chronic kidney disease; rats

PMID:
28542915
DOI:
10.1111/jphp.12748
[Indexed for MEDLINE]

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