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J Cell Physiol. 2018 Mar;233(3):1897-1912. doi: 10.1002/jcp.26017. Epub 2017 Jun 15.

Intimate connections: Inositol pyrophosphates at the interface of metabolic regulation and cell signaling.

Author information

1
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.

Abstract

Inositol pyrophosphates are small, diffusible signaling molecules that possess the most concentrated three-dimensional array of phosphate groups in Nature; up to eight phosphates are crammed around a six-carbon inositol ring. This review discusses the physico-chemical properties of these unique molecules, and their mechanisms of action. Also provided is information on the enzymes that regulate the levels and hence the signaling properties of these molecules. This review pursues the idea that many of the biological effects of inositol pyrophosphates can be rationalized by their actions at the interface of cell signaling and metabolism that is essential to cellular and organismal homeostasis.

KEYWORDS:

cell signaling; inositol pyrophosphates; kinase; metabolism; phosphatase

PMID:
28542902
PMCID:
PMC5694711
DOI:
10.1002/jcp.26017
[Indexed for MEDLINE]
Free PMC Article

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