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PLoS Pathog. 2017 May 25;13(5):e1006378. doi: 10.1371/journal.ppat.1006378. eCollection 2017 May.

Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques.

Author information

1
Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
2
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
3
Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
4
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
5
School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
6
Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
7
Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
8
Department of Pediatrics and Human Vaccine Institute, Duke University Medical Center, Durham, North Carolina, United States of America.
9
Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
10
Departments of Pediatrics and Cell Biology and Human Anatomy, University of California-Davis, California National Primate Research Center, Davis, California, United States of America.

Abstract

Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.

PMID:
28542585
PMCID:
PMC5444831
DOI:
10.1371/journal.ppat.1006378
[Indexed for MEDLINE]
Free PMC Article

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