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IEEE Trans Biomed Eng. 2017 Jul;64(7):1455-1468. doi: 10.1109/TBME.2016.2619741. Epub 2017 May 23.

Fast Numerical Simulation of Focused Ultrasound Treatments During Respiratory Motion With Discontinuous Motion Boundaries.

Author information

1
Fraunhofer Institute for Medical Image Computing MEVIS, Bremen, Germany.
2
Fraunhofer Institute for Medical Image Computing MEVIS.

Abstract

OBJECTIVE:

Focused ultrasound (FUS) is rapidly gaining clinical acceptance for several target tissues in the human body. Yet, treating liver targets is not clinically applied due to a high complexity of the procedure (noninvasiveness, target motion, complex anatomy, blood cooling effects, shielding by ribs, and limited image-based monitoring). To reduce the complexity, numerical FUS simulations can be utilized for both treatment planning and execution. These use-cases demand highly accurate and computationally efficient simulations.

METHODS:

We propose a numerical method for the simulation of abdominal FUS treatments during respiratory motion of the organs and target. Especially, a novel approach is proposed to simulate the heating during motion by solving Pennes' bioheat equation in a computational reference space, i.e., the equation is mathematically transformed to the reference. The approach allows for motion discontinuities, e.g., the sliding of the liver along the abdominal wall.

RESULTS:

Implementing the solver completely on the graphics processing unit and combining it with an atlas-based ultrasound simulation approach yields a simulation performance faster than real time (less than 50-s computing time for 100 s of treatment time) on a modern off-the-shelf laptop. The simulation method is incorporated into a treatment planning demonstration application that allows to simulate real patient cases including respiratory motion.

CONCLUSION:

The high performance of the presented simulation method opens the door to clinical applications.

SIGNIFICANCE:

The methods bear the potential to enable the application of FUS for moving organs.

PMID:
28541191
DOI:
10.1109/TBME.2016.2619741
[Indexed for MEDLINE]

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