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Future Microbiol. 2017 Jun;12:683-693. doi: 10.2217/fmb-2016-0216. Epub 2017 May 25.

In vitro susceptibility and resistance phenotypes in contemporary Enterobacter isolates in a university hospital in Crete, Greece.

Author information

1
Department of Clinical Microbiology, University Hospital of Heraklion, Heraklion, Greece.
2
Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.
3
Department of Medicine, Henry Dunant Hospital Center, Athens, Greece.
4
Department of Internal Medicine, University of Crete School of Medicine, Heraklion, Greece.
5
Department of Applied Mathematics & Physics, National Technical University of Athens, Athens, Greece.
6
School of Medicine, University of Crete, Heraklion, Greece.
7
Department of Medicine, Tufts University School of Medicine, Boston, MA 02155, USA.

Abstract

AIM:

To study the evolution in the susceptibility of Enterobacter spp. in Crete, Greece from 2010 to 2015.

METHODS:

Non-duplicate isolates were studied using automated systems. Phenotypic confirmatory tests were applied.

RESULTS:

A total of 939 Enterobacter isolates were included. Colistin was the most active antibiotic (97.9%) followed by imipenem (96.1%), gentamicin (95.7%), tigecycline (91.8%), cefepime (89.4%), chloramphenicol (85.8%), fosfomycin (85.5%), trimethoprim/sulfamethoxazole (83.3%) and piperacillin/tazobactam (73.3%). Antibiotic resistance did not increase during the study period for most antibiotics. Lower susceptibility was observed among multidrug-resistant strains and carbapenem-nonsusceptible isolates. AmpC was the most common resistant mechanism (21%); carbapenemases (3.7%) and aminoglycoside-modifying enzymes (6.5%) were also detected.

CONCLUSION:

A significant proportion of Enterobacter spp. was resistant to several antibiotics, most notably β-lactams.

KEYWORDS:

AAC(3); AAC(6′); ESBL; KPC; OXA; metallo-β-lactamase

PMID:
28540747
DOI:
10.2217/fmb-2016-0216
[Indexed for MEDLINE]

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