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Sci Rep. 2017 May 24;7(1):2360. doi: 10.1038/s41598-017-02546-x.

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial.

Author information

1
Department of Human Biology, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands. emanuel.canfora@maastrichtuniversity.nl.
2
Top Institute Food and Nutrition, 6700AN, Wageningen, The Netherlands. emanuel.canfora@maastrichtuniversity.nl.
3
Top Institute Food and Nutrition, 6700AN, Wageningen, The Netherlands.
4
Department of Surgery, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands.
5
Department of Human Biology, NUTRIM 'School of Nutrition and Translational Research in Metabolism', Maastricht University Medical Centre, 6229ER, Maastricht, The Netherlands.
6
NNF Center for Basic Metabolic Research, Department of Biomedical Sciences, The Panum Institute, University of Copenhagen, 2200, Copenhagen, Denmark.
7
Department of HPB Surgery and Liver Transplantation, Institute of Liver and Digestive Health, University College London, WC1 6HX, London, United Kingdom.
8
Department of Surgery, Universitätsklinikum Aachen, 52074, Aachen, Germany.

Abstract

Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25-35 kg/m2) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.

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